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Nephrology Dialysis Transplantation, Vol 12, Issue 4 691-693, Copyright © 1997 by Oxford University Press


ORIGINAL ARTICLES

Preliminary evidence for a role of apolipoprotein E alleles in identifying haemodialysis patients at high vascular risk

M Olmer, JE Renucci, R Planells, D Bouchouareb and R Purgus
Nephrology-Dialysis Department, Hopital de la Conception, Marseille, France.

Conventional risk factors have very low predictive power in identifying haemodialysis patients at high risk of vascular accidents. A role for apolipoprotein E isotypes was looked for in a small, but rigorously defined, cohort of longterm haemodialysis patients. In individuals with high vascular risk, as identified by higher common carotid intima/media thickness, we found an excess of apolipoprotein E4 alleles. This preliminary result requires confirmation in large patient cohorts.
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