Nephrology Dialysis Transplantation, Vol 12, Issue 4 691-693, Copyright © 1997 by Oxford University Press
M Olmer, JE Renucci, R Planells, D Bouchouareb and R Purgus
Conventional risk factors have very low predictive power in identifying
haemodialysis patients at high risk of vascular accidents. A role for
apolipoprotein E isotypes was looked for in a small, but rigorously
defined, cohort of longterm haemodialysis patients. In individuals with
high vascular risk, as identified by higher common carotid intima/media
thickness, we found an excess of apolipoprotein E4 alleles. This
preliminary result requires confirmation in large patient cohorts.
ORIGINAL ARTICLES
Preliminary evidence for a role of apolipoprotein E alleles in identifying haemodialysis patients at high vascular risk
Nephrology-Dialysis Department, Hopital de la Conception, Marseille, France.
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