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Nephrology Dialysis Transplantation, Vol 12, Issue 9 1961-1962, Copyright © 1997 by Oxford University Press

BRIEF REPORTS

Autoantibodies against a kidney-liver protein associated with quinolone-induced acute interstitial nephritis or hepatitis

A Gauffre, J Mircheva, D Glotz, F Fillastre, P Simon, P Baune and P Druet
INSERM U 75, CHU Necker, Universite Rene Descartes, 156 rue de Avaugirard, 75730 Paris Cedex 15, France; INSERM U 28, Hopital Broussais, Paris, France; Hopital Boisguillaume, Boisguillaume, France; Centre Hospitalier de Saint-Brieuc, France; Corresponding author

In the present study we report on four cases of acute interstitial nephritis (AIN) and two cases of hepatitis induced by quinolone. We show by immunoblotting analysis that all sera from these patients contained autoantibodies that recognize a 65-kDa protein expressed in normal human kidney and liver microsomes. Only 6% of sera from healthy individuals who did not ingest quinolone recognized the same protein. These findings suggest that the presence of autoantibodies could be used as a sensitive marker and that a modification of microsomal proteins by quinolone itself or by a metabolite could generate an autoimmune response. Keywords: quinolone; acute interstitial nephritis; hepatitis; autoantibodies; P-450
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