Nephrology Dialysis Transplantation, Vol 13, Issue 5 1176-1182, Copyright © 1998 by Oxford University Press
E Brandstrom, A Grzegorczyk, L Jacobsson, P Friberg, A Lindahl and M Aurell
Background: The aim of the present study was to
compare the most commonly used GFR markers for clearance measurements,
51Cr-EDTA and iohexol, using two different methods
for iohexol analysis, HPLC and X-ray fluorescence, referring both to the
multiple-sample and single-sample calculations, using
51Cr-EDTA as the reference method.
Methods: Forty-nine patients with an estimated GFR
>40 ml/min were included. 51Cr-EDTA and
iohexol were injected simultaneously and blood samples were taken 150, 195
and 240 min after injection of the respective marker.
Results: The multiple-point clearances, determined
from HPLC and X-ray fluorescence, compared to
51Cr-EDTA correlated highly (r=0.92 and 0.95
respectively). The results from single-point clearance comparison, iohexol
measured by HPLC vs 51Cr-EDTA
yielded a correlation of r=0.91 and an intercept statistically different
from origo. Conclusions: Iohexol
and 51Cr-EDTA are comparable as GFR markers for
multiple-point clearance measurements. The single-sample method for GFR
>40 ml/min can be used with a high accuracy. The precision and
accuracy of X-ray fluorescence analysis of low concentrations of iohexol
were less than those of HPLC. Care should therefore be taken when using
X-ray fluorescence that the injected dose of iohexol should result in a
plasma concentration level of iodine of at least 0.06 mg/ml at the time of
blood sampling. Key words: Cr-EDTA clearance; iohexol;
glomerular filtration rate
ORIGINAL ARTICLES
GFR measurement with iohexol and 51Cr-EDTA. A comparison of the two favoured GFR markers in Europe
Departments of Clinical Physiology, Clinical Chemistry, Radiation Physics and Nephrology, Sahlgrenska University Hospital, S-413 45 Goteborg, Sweden; Corresponding author
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