Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Luippold, G.
Right arrow Articles by Mühlbauer, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Luippold, G.
Right arrow Articles by Mühlbauer, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (2004) 19: 342-347
© ERA–EDTA 2004; all rights reserved

Original Article

Chronic renal denervation prevents glomerular hyperfiltration in diabetic rats

Gerd Luippold, Martina Beilharz and Bernd Mühlbauer

Department of Pharmacology and Toxicology, Faculty of Medicine, University of Tübingen, Tübingen, Germany

Correspondence and offprint requests to: Dr G. Luippold, Department of Pharmacology and Toxicology, Faculty of Medicine, University of Tübingen, Wilhelmstrasse 56, D-72074 Tübingen, Germany. Email: gerd.luippold{at}uni-tuebingen.de

Background. The increase in glomerular filtration rate (GFR) induced by amino acid infusion is attenuated in rats with chronic renal denervation. The aim of the present study was to investigate whether renal denervation abrogates glomerular hyperfiltration occurring in the early state of diabetes mellitus.

Methods. Sprague–Dawley rats were subjected to bilateral renal denervation before induction of diabetes mellitus (DM) by streptozotocin. Clearance experiments were performed 2 weeks after onset of moderate DM. Glomerular volume was estimated following paraformaldehyde fixation in rat kidney slices from measurement of cross-sectional area of Bowman's capsule.

Results. GFR in non-diabetic rats with intact nerves (CON-INN) was 0.82±0.03 ml·min–1·100 g–1 body weight. Diabetic animals with innervated kidneys presented a significant glomerular hyperfiltration (1.13±0.03 ml·min–1·100 g–1 body weight), while renal denervation in diabetic rats lowered GFR towards levels of CON-INN (0.88±0.03 ml·min–1·100 g–1 body weight). Estimated glomerular volume amounted to 0.69±0.03·106 µm3 in the CON-INN group and was significantly higher in diabetic animals with intact renal nerves (0.86±0.04·106 µm3). Interestingly, renal denervation prevented the glomerular enlargement due to DM.

Conclusions. Renal nerves appear to be significantly involved in the mediation of glomerular hyperfiltration in experimental DM. If the kidney is prevented from sympathetic nerve stimulation, structural changes due to early diabetic nephropathy, i.e. glomerular enlargement, are abolished.

Keywords: diabetes mellitus; glomerular hyperfiltration; rats; renal denervation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 HypertensionHome page
D. I. Diz
Lewis K. Dahl Memorial Lecture: The Renin-Angiotensin System and Aging
Hypertension, July 1, 2008; 52(1): 37 - 43.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.