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NDT Advance Access originally published online on October 12, 2007
Nephrology Dialysis Transplantation 2008 23(3):853-859; doi:10.1093/ndt/gfm691
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Preventive effect of nebivolol on contrast-induced nephropathy in rats

Omer Toprak1, Mustafa Cirit1, Mehmet Tanrisev1, Cevat Yazici2, Ozlem Canoz3, Murat Sipahioglu4, Atilla Uzum1, Rifki Ersoy1 and Eser Yildirim Sozmen5

1 Department of Nephrology, Ataturk Training and Research Hospital, Izmir, Turkey 2 Department of Biochemistry, Erciyes University School of Medicine, Kayseri, Turkey 3 Department of Pathology, Erciyes University School of Medicine, Kayseri, Turkey 4 Department of Medicine, Division of Nephrology, Erciyes University School of Medicine, Kayseri, Turkey 5 Department of Biochemistry, Ege University School of Medicine, Izmir, Turkey

Omer Toprak, MD, Ataturk Training and Research Hospital, Department of Nephrology, 35360 Izmir, Turkey. Tel: +90-505-4411635; Fax: +90-232-2434848; E-mail: info{at}omertoprak.com



  Abstract

Background. Altered renal vasodilatation and oxidative stress are important mechanisms of contrast-induced nephropathy (CIN). The aim of the present study was to assess the effect of nebivolol, a beta blocker, on prevention of CIN. We hypothesized that nebivolol may prevent CIN due to its renal vasodilatation and antioxidant effects.

Methods. Thirty-two Wistar-albino rats were divided into four groups (n = 8 each): control (C), contrast media (CM), nebivolol (N), and nebivolol + contrast media (NCM). CIN was induced by administration of intravenous high-osmolar contrast media diatrizoate (6 ml/kg) after 72 h of dehydration. Nebivolol (2 mg/kg) was given internally once daily for 5 days. Kidney function parameters, nitric oxide metabolites and oxidative stress markers were measured. Kidneys were excised for pathological evaluation.

Results. The decrease of creatinine clearance was 0.180 ± 0.11 mg/dl in CM, and 0.030 ± 0.10 mg/dl in NCM (P = 0.01). Microproteinuria was ameliorated using nebivolol (P = 0.001). Serum protein carbonyl content, malonyldialdehyde and kidney thiobarbituric acid-reacting substances levels were higher in CM than in C (P = 0.003, P < 0.001 and P = 0.034, respectively) and serum thiol was lower in CM than in C (P = 0.001). However, oxidative stress markers were similar in NCM and C. Diatrizoate decreased kidney nitrite levels, but nebivolol increased them (P = 0.027). Nebivolol attenuated the tubular necrosis, proteinaceous casts and medullary congestion, although significant protective effects, were observed in tubular necrosis (P = 0.001) and proteinaceous cast (P < 0.001).

Conclusion. This study demonstrated the protective role of nebivolol against CIN.

Keywords: contrast-induced nephropathy; contrast media; nebivolol; nitric oxide; oxidative stress

Received for publication: 17. 7.07
Accepted in revised form: 6. 9.07


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