Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (51)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Young, G. A.
Right arrow Articles by Brownjohn, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Young, G. A.
Right arrow Articles by Brownjohn, A. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (1989) 4: 285-292
© 1989 European Renal Association-European Dialysis and Transplant Association

research-article

The Use of an Amino-acid-based CAPD Fluid over 12 Weeks

G. A. Young1,, J. B. Dibble2, S. M. Hobson1, L. Tompkins2, J. Gibson2, J. H. Turney2 and A. M. Brownjohn2

1Renal Research Unit, General Infirmary Leeds, UK 2Renal Unit, General Infirmary Leeds, UK

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr G. A. Young, Scientific Director, Renal Research Unit, General Infirmary, Leeds LSI 3EX, UK. Telephone Leeds 432799 Ext. 2544).

Eight patients with end-stage renal failure (plasma albumin less than 35 g/l) who were established on glucose CAPD exchanges, were studied for 4-week periods before, and after 12 weeks when 1% amino-acid solution had been used for the morning exchange. Anthropometric, biochemical, clinical and dietary assessments were made every 4 weeks. Dietary intakes of protein and calories were maintained.

Studies with amino-acid solutions showed a mean of 13% and 8% amino acids remaining in the dialysate after 6 and 8 h respectively. Plasma amino acids increased to a maximum after 2 h of dialysis; however, fasting concentrations were constant over the 5 months. Osmolality of amino acids decreased comparably with 1.36% glucose during 8-h exhanges although the recovery of fluid was marginally less. Plasma transferrin increased significantly after 8 weeks of amino acids but subsequently decreased in one patient due to infection. No significant changes occurred in albumin, apolipoprotein A, IgG, IgA or prealbumin. Cholesterol and apolipoprotein B decreased in seven patients but increased in one due to rising calorie intake. Increases in urea and decreases in bicarbonate were not clinically significant.

Amino-acid-based fluid was well tolerated with modest nutritional benefit and reduction in hyperlipidaemia. Optimal effects of amino acids are likely at higher concentrations using two or more exchanges in patients eating less than 0.9 g protein/kg per day.

Keywords: Amino acids; CAPD; Nutrition; Osmotic agents


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
H. L. Tjiong, J. W. van den Berg, J. L. Wattimena, T. Rietveld, L. J. van Dijk, A. M. van der Wiel, A. M. van Egmond, M. W. Fieren, and R. Swart
Dialysate as Food: Combined Amino Acid and Glucose Dialysate Improves Protein Anabolism in Renal Failure Patients on Automated Peritoneal Dialysis
J. Am. Soc. Nephrol., May 1, 2005; 16(5): 1486 - 1493.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.