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Nephrol Dial Transplant (1992) 7: 1249-1251
© 1992 European Renal Association-European Dialysis and Transplant Association

other

1{alpha}-Hydroxycholecalciferol adsorption to peritoneal dialysis bags: influence of time, glucose concentration, temperature, and albumin

P. Joffe, S. D. Ladefoged, C. Cintin and H. Lehmann

Departments of Nephrology, Herlev County Hospital and Hvidovre Hospital, University of Copenhagen Denmark

Correspondence and offprint requests to: Preben Joffe M D, Department of Nephrology B 109, Herlev Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark.

The present study examines the adsorptive phenomenon of l{alpha}-hydroxycholecalciferol (l{alpha}-0HD3) to peritoneal dialysis bags. One minute after injection of l{alpha}-OHD3 into the dialysis bags, a significant adsorption to the bags was observed in experiments where albumin was not added. A higher temperature (37° versus 23°C) in bags containing 13.6 mg glucose/ml resulted in less adsorption (P<0.05). Adding albumin to bags at 37°C with a glucose concentration of 13.6mg/ml, reduced the adsorptive phenomenon significantly (p<0.01). Bags tested at 37°C with a glucose concentration of 38.6 mg/ml resulted in a significantly higher l{alpha}-OHD3 adsorption than bags containing 13.6 mg glucose/ml (p<0.01)

It is concluded that adsorption of l{alpha}-0HD3 to dialysis bags is affected by time, albumin, temperature and glucose concentrations. Substantial amounts of l{alpha}-0HD3 is retained by the peritoneal dialysis system when albumin is not added.

Keywords: 1{alpha}-hydroxycholecalciferol; adsorption; peritoneal dialysis fluid; plastic bags; PVC material


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