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Nephrol Dial Transplant (1992) 7: 340-345
© 1992 European Renal Association-European Dialysis and Transplant Association

research-article

Cellulose-based haemodialysis membranes: Biocompatibility and functional performance compared

Celia Woffindin1, N. A. Hoenich1, and J. N. S. Matthews2

1Departrnent of Medicine, School of Clinical Medical Sciences Newcastle upon Tyne, UK 2Division of Medical Statistics, School of Health Care Sciences, Medical School Newcastle upon Tyne, UK

Correspondence and offprint requests to: N.A. Hoenich, Department of Medicine, School of Clinical and Medical Sciences, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK

Regenerated cellulose membranes are widely used in the treatment of renal failure. The presence of hydroxyl (OH) groups on the membrane surface plays an important role in initiating complement activation and also influences thrombogenicity. The OH groups may be masked or reduced by alteration of the manufacturing process of the membrane. We have undertaken a clinical study of four cellulose-based membranes (Cuprophan, Hemophan, cellulose acetate, and cellulose triacetate) in which the hydroxyl groups of the membrane have been replaced and the magnitude of replacement has varied from < 1% to >80%, to assess the role that these modifications play in functional performance, biocompatibility (neutropenia, leukocyte activation, anaphylatoxin generation, and hypoxaemia). Our findings indicate that there does not appear to be a straightforward correlation between the numbers of hydroxyl groups replaced and modification of biocompatibility, suggesting that not all hydroxyl groups behave in a similar way.

Keywords: haemodialysis; biocompatibility; cellulosic membranes


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