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Nephrol Dial Transplant (1992) 7: 346-349
© 1992 European Renal Association-European Dialysis and Transplant Association

research-article

High incidence of post-transplant diabetes mellitus in a single-centre study

J. K. Onwubalili and E. N. Obineche

Nephrology Unit, Department of Medicine, King Fahad Hospital at Al Baha Saudi Arabia

Correspondence and offprint requests to: Dr J. K. Onwubalili, Consultant Nephrologist, King Fahad Hospital at Al Baha, P O Box 204, Al Baha, Saudi Arabia

Twelve of 29 Saudi patients (41.4%) developed diabetes mellitus following renal transplantation. Post-transplant diabetes mellitus occurred within the first 2 months in eight patients; two others presented with diabetic ketoacidosis associated with severe infections. The diabetic and non-diabetic patients had received similar doses of prednisolone and cyclosporin (CsA) during the initial 2 months post-transplantation, and their mean CsA blood values at 3 months were not significantly different. Increasing patient age (over 40 years), but not sex, donor source, or body mass index, was associated with an increased risk for developing diabetes mellitus. Post-transplant diabetes mellitus was controlled with oral hypoglycaemic agents in most patients, but one-third required insulin. Patients who developed diabetes had significantly decreased mean creatinine clearance/1.73 m2 at a mean graft age of 3.4 years (P< 0.001). Diabetes mellitus after transplantation may be more common among Saudi patients than elsewhere, especially those aged over 40 years. It develops rapidly, may present with ketosis, and is associated with graft dysfunction.

Keywords: cyclosporin; diabetic ketoacidosis; posttransplant diabetes mellitus; renal transplantation


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