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Nephrol Dial Transplant (1992) 7: 501-506
© 1992 European Renal Association-European Dialysis and Transplant Association

research-article

The response of GFR to amino acids differs between autosomal dominant polycystic kidney disease (ADPKD) and glomerular disease

M. Zeier, M. Schmid, R. Nowack, S. Zacharewics, Ch. Hasslacher and E. Ritz

Department of Internal Medicine, University of Heidelberg Heidelberg, Germany

Correspondence and offprint requests to: Correspondence and offprint requests to: Martin Zeier MD, Department of Internal Medicine, University of Heidelberg, Bergheimer-StraBe 58, 6900 Heidelberg, Germany.

We compared the glomerular filtration rate (GFR) response to amino acids in patients with glomerular disease and polycystic kidney disease. The GFR response to infusion of amino acids (75 g/12 h), of dopamine (2 µg/kg per min), or their combination was evaluated in nine healthy probands and in patients with two types of renal diseases at various degrees of renal function: 15 patients with ADPKD and 11 patients with glomerular disease (IgA glomerulonephritis or diabetic nephropathy). Steady-state inulin infusion technique was used. In healthy subjects amino acids increased median Cin in response to amino acids was not found in glomerular disease. In contrast in most ADPKD patients median Cln increased after amino acids ( + 6.0 ml/min; range –4 to +68), (P<<0.05). The response to amino acids was not modified by dopamine. The results demonstrate that amino acid-induced acute changes of glomerular filtration differ in polycystic kidney disease compared with glomerular disease. These observations may have implications with respect to mechanisms of progression.

Keywords: ADPKD (autosomal dominant polycystic kidney disease); amino acids; progression of renal failure; glomerular filtration; renal reserve capacity


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