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Nephrol Dial Transplant (1992) 7: 530-533
© 1992 European Renal Association-European Dialysis and Transplant Association

research-article

T{gamma}/{delta} lymphocytes in renal transplant recipients

M. H. M. Raasveld1,2, E. Bloemena1, S. Surachno2 and R. J. M. ten Berge1,2,

1Clinical Immunology Laboratory, Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam The Netherlands 2Renal Transplant Unit, Department of Internal Medicine, Academic Medical Centre, University of Amsterdam Amsterdam, The Netherlands

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr R. J. M. ten Berge, Academic Medical Centre, Department of Internal Medicine, Renal Transplant Unit, F4-215, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

T {gamma}/{delta} lymphocytes are able to perform allospecific cytotoxicity and natural killer cytotoxicity in vitro. However, very little is known about their function in vivo. To investigate the possible involvement of T {gamma}/{delta} lymphocytes in the immune response to renal allografts, fine-needle aspiration biopsies and peripheral blood of 15 renal transplant recipients were studied during the first 4 weeks after transplantation. In addition peripheral blood of patients before transplantation, half a year and one year after transplantation was studied. No increase in the percentage of T {gamma}/{delta} lymphocytes in the fine-needle aspiration biopsies, including those taken during acute rejection episodes, was found. A significant decrease in the percentage of T {gamma}/{delta} lymphocytes was observed in peripheral blood after transplantation. We conclude that T {gamma}/{delta} lymphocytes seem to play no major role in the immune response to renal allografts.

Keywords: acute rejection; {gamma}/{delta} T cells; renal transplantation


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