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Nephrol Dial Transplant (1992) 7: 534-538
© 1992 European Renal Association-European Dialysis and Transplant Association

brief-report

Antineutrophil cytoplasmic antibodies in IgA nephropathy and Henoch–Schönlein purpura

D. J. O'Donoghue1,, P. Nusbaum2, L.-H. Noel2, L. Halbwachs-Mecarelli2 and Ph. Lesavre2

1Medical Renal Unit, Royal Infirmary of Edinburgh Edinburgh, UK 2Department of Nephrology, Hospital Necker Paris, France

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr D. J. O'Donoghue, Medical Renal Unit, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, UK.

The frequency, isotype, and specificity of antineutrophil cytoplasmic antibodies were investigated in a cross-sectional study of 100 patients with IgA nephropathy and 30 children with Henoch–Schönlein purpura. Two of the patients with IgA nephropathy had high titres of antineutrophil cytoplasmic antibodies which were of IgG isotype and confirmed as antimyeloperoxidase antibodies in solidphase ELISA and inhibition experiments. Antineutrophil cytoplasmic antibodies were not detected in the children with Henoch–Schönlein purpura and none of the patients in either group had IgA antineutrophil cytoplasmic antibodies. A further 20 IgA nephropathy and 10 Henoch–Schönlein purpura patients were studied longitudinally in different clinical phases at 4-monthly intervals over a 2-year period. None of these patients had or developed antineutrophil cytoplasmic antibodies. We conclude that IgA antineutrophil cytoplasmic antibodies are not involved in the vasculitis of Henoch–Schönlein purpura or in the pathogenesis of glomerular injury in IgA nephropathy. The detection of IgG antimyeloperoxidase antibodies in a small minority of IgA nephropathy patients extends the spectrum of diseases associated with autoimmunity to this antigen but is of uncertain significance.

Keywords: antineutrophil cytoplasmic antibodies


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