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Nephrol Dial Transplant (1992) 7: 840-843
© 1992 European Renal Association-European Dialysis and Transplant Association

research-article

Sonographic evaluation of gallbladder motility in patients with end-stage renal disease on haemodialysis

U. Gladziwa1, S. Wagner3, R. Kock2, H. Mann1 and H.-G. Sieberth1

1Department of Internal Medicine II Medizinische Hochschule Hannover, Germany 2Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Aachen Medizinische Hochschule Hannover, Germany 3Department of Gastroenterology and Hepatology Medizinische Hochschule Hannover, Germany

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr U. Gladziwa Department of Internal Medicine II, Technical University of Aachen, Pauwelsstr. 30, W-5100 Aachen, Germany.

Thirty nine patients with end-stage renal disease on haemodialysis therapy with upper gastrointestinal symptoms were investigated for gallbladder motor function as the cause of their symptoms using cholecystosonography in fasting state, after a cholecystokinetic agent (BILOPTTN fatty meal) and after a smooth muscle relaxant (BUSCOPAN). Forty healthy individuals served as a control group. No significant difference was found between dialysis patients and healthy controls regarding the gallbladder area during fasting state, or the variation in the area of gallbladder during maximal contraction and dilatation. However, the patients on dialysis therapy of longer duration had stronger gallbladder contraction in response to a cholecystokinetic agent. Serum gastrin concentrations were increased in haemodialysis patients, but there was no consistent relationship between serum gastrin and gallbladder motility. The upper gastrointestinal symptoms of dialysis patients are unlikely to be due to disturbed gallbladder motility.

Keywords: cholecystosonography; gallbladder motility; gastrin; haemodialysis patients; renal failure


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