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Nephrol Dial Transplant (1992) 7: 924-930
© 1992 European Renal Association-European Dialysis and Transplant Association

research-article

Failure of a daily haemofiltration programme using a highly permeable membrane to return ß2-microglobulin concentrations to normal in haemodialysis patients

B. Canaud, A. Assounga, P. Kerr, R. Aznar and C. Mion

Nephrology Division Lapeyronie University Hospital Montpellier, France

Correspondence and offprint requests to: Correspondence and offprint requests to: B Canaud, Nephrology Division, Lapeyronie University Hospital, 555, Route de Ganges, 34059 Montpellier, France.

In an attempt to return to normal serum ß2-microglobulin levels in a group of seven ESRD patients, a programme of daily HF with highly permeable AN69 membranes was undertaken. Pre-HF ß2-M serum levels stabilized after 4 days at 20 mg/1,only 40% lower than the initial concentration. A total of 985±20 mg ß2-M was removed over theweek. The ß2-M release rate averaged 97 µg/min witha broad range of values (63–128 µg/min). ß2-M release peaked at 602 µg/min 1 h after the end of the HF session before returning to baseline by 12 h post-HF. We conclude that a return to normal blood ß2-M concentrations in ESRD patients seems quite unrealistic despite a highly intensive extracorporeal therapy. Therefore other therapeutic alternatives have to be designed to prevent or cure ß2-M amyloidosis.

Keywords: ß2-M amyloidosis; ß2-M; end-stage renaldisease; haemofiltration; highly permeable mem-branes; ß2-M kinetic modelling


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