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Nephrol Dial Transplant (1992) 7: 939-943
© 1992 European Renal Association-European Dialysis and Transplant Association

research-article

Aluminium overload and response to recombinant human erythropoietin in patients under chronic haemodialysis

O. Alfurayh, M. Sobh, Y. Barri, W. Qunibi and S. Taher

Section of Nephrology, Department of Medicine, King Faisal Specialist Hospital and Research Centre Riaydh, Saudi Arabia

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr Osman Alfurayh, Head,Section of Nephrology, Department of Medicine (MBC-46), King Faisal Specialist Hospital and Research Centre P.O. Box 3354, Riyadh 11211, Saudi Arabia.

In this work, of 51 patients treated by rHuEpo, 25 were selected for study. The selection criteria were absence of clinically evident causes of anaemia other than end-stage renal failure, such as chronic infection, active systemic disease, bleeding sites, and vitamin B12 or iron deficiencies. Serum aluminium was assessed before dialysis and the presence of aluminium overload was confirmed by a DFO test. rHuEpo was given in a dose of 50 U/kg bodyweight after each dialysis session three times weekly and the response to treatment was evaluated monthly for 8 months. Our data showed significant correlation between serum aluminium and the response to rHuEpo. The response was significantly greater in those with lower serum aluminium. We conclude that the aluminium load in chronic haemodialysis patients may have an effect on the response to rHuEpo.

Keywords: aluminium; erythropoietin; haemodialysis


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