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Nephrol Dial Transplant (1993) 8: 25-28
© 1993 European Renal Association-European Dialysis and Transplant Association

research-article

Elevation of IgA in IgA nephropathy is localized in the serum and not saliva and is restricted to the IgA1 subclass

L. Layward, A. C. Allen, J. M. Hattersley, S. J. Harper and J. Feehally

Department of Nephrology, Leicester General Hospital Leicester, UK

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr J. Feehally, Department of Nephrology, Leicester General Hospital, Gwendolen Road, Leicester. LE5 4PW, UK.

Glomerular deposits in IgA nephropathy (IgAN) are predominantly IgAl but their origin is not known. Previous studies have analysed serum or saliva IgA, but not in the same patients. To investigate whether IgA and IgA subclass anomalies occur in IgAN at both mucosal and systemic sites, blood and saliva from 20 patients and 20 age- and sex-matched controls were studied. Patients with IgAN had significantly increased serum IgA (P< 0.002), and this elevation was restricted to the IgAl subclass. Serum IgAl was also increased significantly (P<0.001) but IgA2 was not. By contrast salivary IgA, IgAl, and IgA2 did not differ significantly from the controls. These results demonstrate that the elevated serum IgA is predominantly IgAl and is likely to be of systemic origin. Further studies should consider the bone marrow as a potential source of the elevated IgAl.

Keywords: IgA; IgA nephropathy; IgA subclasses; saliva; serum


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