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Nephrol Dial Transplant (1993) 8: 47-53
© 1993 European Renal Association-European Dialysis and Transplant Association

research-article

Biocompatibility of a new high-permeability modified cellulose membrane for haemodialysis

R. A. Ward1,, R. M. Schaefer3, D. Falkenhagen4, M. S. Joshua2, A. Heidland3, H. Klinkmann4 and H. J. Gurland5

1Division of Nephrology, Department of Medicine, University of Louisville Louisville, Kentucky. USA 2Department of Statistical Unit, University of Louisville Louisville, Kentucky. USA 3Division of Nephrology, Department of Medicine, University of Würzburg Würzburg, Germany 4Department of Internal Medicine, Wilhelm Pieck University Rostock, Germany 5Department of Nephrology, Klinikum Grosshadern, University of Munich Munich, Germany

Correspondence and offprint requests to: Correspondence and offprint requests to: Richard A. Ward, PhD. Division of Nephrology, School of Medicine. University of Louisville, Louisville, Kentucky 40292, USA.

The biocompatibility and solute permeability characteristics of a high-permeability modified cellulose membrane (Hemophan-HP®) (He-HP) were compared with those of two synthetic membranes (poly(ethylene-co-vinyl alcohol) (EVAL) and poly(acrylonitrile-co-sodium methallyl sulphonate) (AN69)) and Cuprophan® in a multicentre, four-way cross-over clinical trial. Cuprophan® membranes caused significant complement activation, leukopenia, and granulocyte elas-tase release. He-HP membranes demonstrated a lesser effect, which was similar to that observed for the EVAL membrane, although less than that seen with the AN69 membrane. A similar order for the four membranes was seen for their effect on platelets. Cuprophan® membranes provided superior small-molecule removal to the other three membranes. In contrast, Cuprophan® was essentially impermeable to ß2-microglobulin, whereas He-HP, EVAL, and AN69 allowed the removal of 60–90 mg of ß2-microglobulin per treatment. However, a decrease in the plasma concentration of ß2-microglobulin was observed only with the AN69 membrane, most probably as a result of the ability of that membrane to adsorb proteins. Our results demonstrate that high-permeability membranes of comparable biocompatibility to some synthetic membranes can be fabricated from cellulose derivatives.

Keywords: biocompatibility; haemodialysis; high-performance; membranes


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