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Nephrol Dial Transplant (1993) 8: 163-167
© 1993 European Renal Association-European Dialysis and Transplant Association

research-article

Cytotoxicity testing of two CAPD dialysis fluids in a model system of quiescent fibroblasts

S. R. Kristensen1, and F. B Pedersen2

1Department of Clinical Chemistry, Odense University Hospital Odense, Denmark 2Department of Nephrology Odense University Hospital Odense, Denmark

Correspondence and offprint requests to: Correspondence and offprint requests to: S. R. Kristensen, Department of Clinical Chemistry, Odense University Hospital, DK-5000 Odense C. Telephone: +45 66113333, ext. 1956

Indications of some bio-incompatibility of fluids used for continuous ambulatory peritoneal dialysis (CAPD) have been found previously. We have tested cytotoxicity of an frequently used dialysis fluid, DianealR, and a new bicarbonate-based dialysis fluid with a pH of 7.4, called 87b, in a model system of quiescent fibroblasts. The ATP level of the cells and release of lactate dehydrogenase was followed during incubation in the dialysis fluids. A marked cytotoxicity of Dianeal was found mainly due to a low pH (5.0–5.5) and to a minor degree because of the lack of potassium and glutamine. 87b was less cytotoxic but it also lacked potassium and glutamine.

Keywords: CAPD; cytotoxicity; fibroblasts; glutamine; bicarbonate; lactate


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