Nephrol Dial Transplant (1994) 9: 1412-1417
© 1994 European Renal Association-European Dialysis and Transplant Association
research-article
Expression of adhesion molecules in poststreptococcal glomerulonephrities
Renal Service and Laboratory, Hospital Universitario de Maracaibo, Instituto de Investigaciones Biomèdicas(INBIOMED) Venezuela
Correspondence and offprint requests to: Correspondence and offprint requests to: Gustavo Parra MD, Apartado Postal 1430, Maracaibo 4001-A, Estado Zulia, Venezuela. Part of this study was presented at the 30th Congress of the European Dialysis and Transplant Association-European Renal Association, Glasgow, September 1993
Because adhesion properties of leukocytes are important for the influx and localization of leukocytes in sites of inflammation, we studied, the expression of intercellular adhesion molecule 1 (ICAM-1), lymphocyte-function-associated antigen 1 (LFA-1), vascular cell adhesion molecule- I (VCAM-l) and CD 11b in 14 kidney biopsies of PSGN patients, arbitrarily divided into early biopsies (less than 15 days after onset of PSGN) and late biopsies (17–90 days). In PSGN, intraglomerular ICAM-1 expression was increased in early biopsies (score 3.1 ±SEM 0.2; P<0.005) and decreased with time; in late biopsies the score (2.0±0.2) was similar to that of normal kidney (1.3±0.3). In the interstitium ICAM-1 was increased (early PSGN=836±56 positive cells/mm2 late=552±60.0; versus normal=364±12.4; P<0.05). LFA-l expressing cells in glomeruli were also increased in early biopsies (10.0±2.1 positive cells per glomerular cross-section (gcs), versus normal 2.9±1.4; P<0.05). In the interstitium, LFA-1 positive cells were increased (early PSGN= 221±79.6 cells/mm2 late PSGN=134.5±45.1, normal=21±8.7; P<0.05). VCAM-l in glomeruli and interstitium was not increased in PSGN.
Our studies demonstrate increased expression of adhesion molecules ICAM-l and LFA-1 in the kidney of PSGN patients, and these findings were more pronounced in early biopsies; adhesion molecules are probably involved in the inflammatory infiltration of this disease.
Keywords: poststreptococcal nephritis; leukocytes; adhesion molecules; T-lymphocytes
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