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Nephrol Dial Transplant (1994) 9: 1474-1476
© 1994 European Renal Association-European Dialysis and Transplant Association

research-article

In-vitro steroid sensitivity in patients with chronic uraemia and renal transplantation: possible association with HLA phenotypes

I. Kovanecz, É. Csajbók and I. B. Petri

Blood Transfusion Centre, Albert Szentgyörgyi Medical University Szeged, Hungary

Correspondence and offprint requests to: Correspondence and offprint requests to:István Kovanecz, Department of Pharmacology, Albert Szent-Györgyi Medical University, H-6701, Szeged, Dóm tér 12. P.O. Box: 115

We studied in-vitro steroid sensitivity using the test of ADCC in 207 haemodialysed chronic uremic patients, 85 renal transplant patients, and 75 healthy blood donors as normal controls. The association of HLA phenotypes with the in-vitro steroid sensitivity was assessed. The proportion of steroid-sensitive subjects was significantly higher in the normal control group than in the patients. A significant association was observed between HLA B8 carriers and steroid resistance and between HLA DR6 carriers and steroid sensitivity.

Keywords: ADCC; haemodialysed chronic uremic patients; HLA; in-vitro steroid sensitivity; methyl-prednisolone; renal transplant


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