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Nephrol Dial Transplant (1994) 9: 413-415
© 1994 European Renal Association-European Dialysis and Transplant Association

research-article

Effect of cyclosporin and the prostacydin analogue iloprost on human glomerular vasoreactivity

E. Le Guen1,, D. Morel1, B. L'Azou2, J. Cambar2 and L. Potaux1

1Department of Nephrology and Transplantation, Hôpital Pellegrin Bordeaux 2Kidney Pathophysiological Study Group, Faculte de Pharmacie, Bordeaux France

Correspondence and offprint requests to: Correspondence and offprint requests to: E. Le Guen, Dept of Nephrology and Transplantation, Hôpital Pellegrin, 33076 Bordeaux, France

Cyclosporin is known to cause a decrease in renal blood flow and glomerular filtration rate in both humans and animals. These acute modifications are reversible if the drug is withdrawn, and seem to be caused by a local hormonal imbalance between vasoconstricting and vasodilating substances. We studied human glomeruli incubated with either CsA alone, iloprost alone, or CsA + iloprost. Photomicrographs of glomeruli were taken at t0, t1, t2 and t5 mm and glomerular areas were measured with a videoanalyser linked to a computer. Results show a significant vasoconstriction with CsA alone, and no significant modification of glomerular areas with iloprost or CsA + iloprost. We conclude that iloprost prevents CsA-induced vasoconstriction in human glomeruli in vitro.

Keywords: CsA-induced vasoconstriction; iloprost; human glomeruli; PGI2 analogue


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