Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Zehnder, C.
Right arrow Articles by Blumberg, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zehnder, C.
Right arrow Articles by Blumberg, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (1994) 9: 753-757
© 1994 European Renal Association-European Dialysis and Transplant Association

research-article

Influence of dialyser clearance measurement accuracy on haemodialysis prescription based onKt/V

C. Zehnder and A. Blumberg

Division of Nephrology, Kantonsspital Aarau Switzerland

Correspondence and offprint requests to: Correspondence and offprint: requests to: Dr C Zehnder, Division of Nephrology, Kantonsspital, CH-5000 Aarau, Switzerland

Kt/V urea (u) has been used as a measure of adequacy of haemodialysis (HD). However, the accurate assessment of its components is difficult and subject to error in a clinical setting. This study was designed to evaluate different forms of dialyser clearance (K) measurements and their influence on Kt/V. Sixteen patients on high-flux HD were studied at blood flow (Qb) rates of 250 and 350 ml/min and at constant dialysate flow rates. K of urea was measured by the arteriovenous blood sampling technique (Kbu), corrected for access recirculation (Kbru) and compared with K as determined by dialysate collection (Kdu) using a new sampling device. At Qb 250 and 350 ml/min, Kbu as based on dialysate collection was significantly lower than Kbru and Kbu as based on arteriovenous blood sampling: at Qb 250, Kdu 169.0± 13.3, Kbru 191.2±11.5, and Kbu 203.0±9.3 ml/min (P<0.0005); at Qb 350, Kdu 196.5±17.3, Kbru 227.7±15.5, and Kbu 243.6±12.7 ml/min (P<0.0005). At Qb 250 ml/min Kbu t/V (1.33±0.17) overestimated Kdu t/V (1.11±0.13) by 16.8%, at Qb 350 ml/min by 19.3% (1.58 ± 0.19 versus 1.27±0.15). Dialyser clearances based on arteriovenous differences in blood overestimate true clearances (and therefore Kt/V) as measured by dialysate collection. This overestimation is more marked with higher blood flow rates.

Keywords: dialyser clearances; dialysate collection; Kt/V


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
J.-P. Gutzwiller, D. Schneditz, A. R. Huber, C. Schindler, F. Gutzwiller, and C. E. Zehnder
Estimating phosphate removal in haemodialysis: an additional tool to quantify dialysis dose
Nephrol. Dial. Transplant., June 1, 2002; 17(6): 1037 - 1044.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
C. Zehnder, J.-P. Gutzwiller, A. Huber, C. Schindler, and D. Schneditz
Low-potassium and glucose-free dialysis maintains urea but enhances potassium removal
Nephrol. Dial. Transplant., January 1, 2001; 16(1): 78 - 84.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.