Nephrol Dial Transplant (1994) 9: 770-774
© 1994 European Renal Association-European Dialysis and Transplant Association
research-article
Circulating soluble adhesion molecules in systemic vasculitis
1Renal Research Laboratories, Queen Elizabeth Hospital Edgbaston, Birmingham 2Department of Immunology, University of Birmingham Birmingham, UK
Correspondence and offprint requests to: Correspondence and offprint requests to Dr. D Adu, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK.
The plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), E-selectin (sE-selectin), and vascular cell adhesion molecule-1 (sVCAM-1), might reflect endothelial activation and injury and would therefore be useful markers of disease activity in vasculitis. To investigate this we measured the levels of sICAM-1, sE-selectin, and sVCAM-1 by two-site ELISAs in the plasma of patients with (a) active vasculitis (n = 16), (b) vasculitis in remission (n = 15), (c) chronic renal failure (CRF) (n = 10), and (d) normal healthy controls (n = 10). Plasma sICAM-1 levels were significantly higher in patients with active vasculitis, 323 ng/ml (193–607) compared with patients with inactive vasculitis, 199 ng/ml (131–297); P = 0.0006 and healthy controls, 188 ng/ml (138–259); P =0.0002. Plasma sE-selectin levels were also significantly higher in the patients with active vasculitis, 45 ng/ml (15–65) compared with patients with inactive vasculitis, 25 ng7sol;ml (15–55); P=0.027 but not when compared with healthy controls, 35 ng/ml (20–55); P=0.16. There was no difference in plasma sVCAM-1 levels between patients with active vasculitis, OD 0.56 (0.45–0.85) and inactive disease, OD 0.58 (0.47–0.79) (P=0.12) or with healthy controls OD 0.49 (0.42–0.68) (P=0.48). There were no significant differences between the plasma levels of any of the soluble adhe sion molecules between patients with active vasculitis and patients with chronic failure. In patients with a vasculitis there was a significant correlation between sICAM-1 and plasma C-reactive protein (CRP) (r=0.60, P=<0.01) and plasma von Willebrand factor (vWF) (r=0.42, P<0.05). Likewise there was a cor relation between sE-selectin and CRP (r=0.45, P<0.02) but not with vWF. There was a significant correlation between sICAM-1 and sE-selectin (r=0.38, P<0.05), but not between sICAM-1 and sVCAM-1 or sE- selectin and sVCAM-1. No correlation was found between sVCAM-1 levels and CRP and vWF concentrations or between the levels of any of the soluble adhesion molecules and serum creatinine. Plasma levels of sICAM-i and of sE-selectin but not of sVCAM-1 reflect disease activity in vasculitis and may be markers of endothelial and or tissue injury in these disorders.
Keywords: vasculitis; endothelium; adhesion molecules
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Ara, E. Mirapeix, P. Arrizabalaga, R. Rodriguez, C. Ascaso, R. Abellana, J. Font, and A. Darnell Circulating soluble adhesion molecules in ANCA-associated vasculitis Nephrol. Dial. Transplant., February 1, 2001; 16(2): 276 - 285. [Abstract] [Full Text] [PDF]
|
|