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NDT Advance Access originally published online on January 12, 2005
Nephrology Dialysis Transplantation 2005 20(2):270-272; doi:10.1093/ndt/gfh667
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Nephrol Dial Transplant Vol. 20 No. 2 © ERA–EDTA 2005; all rights reserved

Editorial Comment

Are PD patients with or without residual renal function qualitatively different—or are they simply at different stages of the continuum of progressive uraemia?

Simon Davies

Department of Nephrology, University Hospital of North Staffordshire, Stoke-on-Trent, UK

Correspondence and offprint requests to: Professor Simon J. Davies, Department of Nephrology, University Hospital of North Staffordshire, Princes Road, Hartshill, Stoke-on-Trent ST4 7LN, UK. Email: SimonDavies1@compuserve.com

Keywords: anuria; inflammation; LV hypertrophy; survival analysis

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The value of residual renal function to patients treated with peritoneal dialysis (PD) is beyond dispute. CANUSA was the first study to demonstrate this, initially expressing the benefit in terms of small solute clearance in combination with peritoneal clearances, although on re-analysis this benefit could be reduced to the simplest of all measures—residual urine volume [1,2]. Nevertheless, CANUSA is often misrepresented. It is the preservation of renal function, not its initial value, that confers benefit, and CANUSA is often taken as evidence that PD as a modality is intrinsically dependent on residual function to deliver adequate patient outcomes. We now know from the NECOSAD database that residual function is equally beneficial to . . . [Full Text of this Article]


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