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NDT Advance Access originally published online on August 25, 2006
Nephrology Dialysis Transplantation 2006 21(10):2681-2683; doi:10.1093/ndt/gfl418
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Translating knowledge of the human genome into clinical practice in nephrology dialysis and transplantation: the renal genome network (ReGeNet)

Paul E. C. Brenchley1,, Bengt Lindholm2, Friedo W. Dekker3, Gerjan Navis4 on behalf of the Renal Genome Network

1Department of Medicine, University of Manchester, Oxford Road, Manchester M13 9PL, UK, 2Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, 3Department of Clinical Epidemiology, Leiden University Medical Centre and 4Department of Pathology, University Medical Centre Groningen, Groningen, The Netherlands

Correspondence and offprint requests to: Prof. Paul Brenchley, Renal Research Labs, Manchester Institute of Nephrology and Transplantation, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK. Email: paul.brenchley@manchester.ac.uk

Keywords: genetic association; human genome; network; regenet; renal disease

The first 150 words of the full text of this article appear below.

The success of unravelling the human genome in 2001 [1] has provided clinical researchers with an estimate of the number of genes, their relative position on chromosomes and access to the entire nucleotide sequence. Despite the promises of the daily press/news that this achievement heralds the introduction of genetically tailored treatment and the answer to every known disease, the reality of the situation is very different. Six years later, nephrologists may justifiably ask how this knowledge of the human genome has had impact on their clinical practices and may correctly conclude that it has made, as yet, a little impact. While encouraging advances have been made in relation to single-gene disorders for a large majority of the renal patient population, renal damage and its complications should be considered as complex traits with contributions of multiple genetic and environmental factors. So, facing this complexity, what is required to translate . . . [Full Text of this Article]



   Developing new knowledge
 


   Developing new ways of working together as a renal research community
 


   Designing specific renal research programmes
 

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