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NDT Advance Access originally published online on December 8, 2007
Nephrology Dialysis Transplantation 2008 23(3):792-799; doi:10.1093/ndt/gfm834
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Gene and protein markers of diabetic nephropathy

Claude Granier1, Kaouthar Makni2, Laurence Molina1, Bénédicte Jardin-Watelet1, Hammadi Ayadi2 and Fayçal Jarraya2,3

1 CNRS FRE3009 SysDiag and Laboratoire International Associé No. 135, Montpellier, France 2 Unité Cibles de Diagnostic et Thérapeutique dans la Pathologie Humaine and Laboratoire International Associé No. 135, Sfax Center of Biotechnology 3 Service de Néphrologie, CHU Hédi Chaker, Sfax, Tunisia

Claude Granier, CNRS FRE3009, Cap Delta/Parc Euromédecine-1682 rue de la Valsière-CS 6100334184, Montpellier, Cedex 4, France. Tel: +33-467-166-619; E-mail: claude.granier@sysdiag.cnrs.fr

Keywords: biomarkers; candidate genes; diabetic nephropathy; diagnostic

The first 150 words of the full text of this article appear below.

Diabetic nephropathy (DN) develops in a large number of type 1 (T1D) and type 2 diabetic (T2D) patients after a variable latency period. DN absolute number is increasing because of greater longevity and the epidemic of diabetes [1]. Although this disease is progressively becoming a heavier burden for the health care system, it is as yet poorly understood in many aspects. The pathogenesis of DN is clearly multifactorial and several genes, proteins and environmental factors are likely to contribute to the onset of the disease. Several metabolic, haemodynamic and intracellular causes have been proposed to play a role in the pathogenesis of DN [2]. Acquired risks also participate in the development of kidney hyperfiltration [3]. As a primary initiator of DN, high glucose level is associated with an increased synthesis of cytokines and growth factors and with the diversion of glucose metabolism into at . . . [Full Text of this Article]



   Genetic predisposition to DN
 
Linkage analysis
Association analysis
Angiotensin-converting enzyme
Aldose reductase
Peroxisome proliferator-activated receptor gamma 2
Glucose transporter 1
Carnosinase


   Urinary protein markers of DN
 
Albumin and non-immunoreactive albumin
Type IV collagen
Adiponectin
Podocytes and nephrin
Advanced glycation end products
Betaig-h3
Identification of urinary markers by proteomic approaches


   Conclusion
 

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