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NDT Advance Access originally published online on November 28, 2007
Nephrology Dialysis Transplantation 2008 23(3):816-819; doi:10.1093/ndt/gfm800
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Th17 cells: a third subset of CD4+ T effector cells involved in organ-specific autoimmunity

Christian Kurts

Institute of Molecular Medicine and Experimental Immunology (IMMEI), Friedrich-Wilhelms-Universität, 53105 Bonn, Germany

Christian Kurts, Institute of Molecular Medicine and Experimental Immunology (IMMEI), Friedrich-Wilhelms-Universität, 53105 Bonn, Germany. Tel: +49-228-287-11031; Fax: +49-228-287-11052; E-mail: ckurts@web.de

Keywords: autoimmunity; cytokines; dendritic cells; interleukin 17; T cells

The first 150 words of the full text of this article appear below.



   The Th1/Th2 paradigm in immunity
 
CD4+ T helper cells orchestrate and regulate adaptive immune responses. From a functional perspective, they can be classified into CD4+ regulatory T cells (Treg) that show immunosuppressive activity and into CD4+ T effector cells that combat infectious pathogens. An important aspect of antimicrobial activity is the choice of the appropriate weaponry suitable to combat a particular class of pathogens. This selection is facilitated by distinct subsets of CD4+ T effector cells that produce cytokines to which the respective immune effectors are responsive. Thus, type 1 CD4+ T effector cells (Th1 cells) secrete IFN{gamma} and TNF{alpha} to recruit macrophages for combating bacterial infections [27], or IL-2 to license cytotoxic CD8+ T cells for killing virally infected cells [8]. They also stimulate B cells to produce opsonizing and neutralizing antibodies that intercept circulating pathogens. In contrast, Th2 cells secrete IL-4, IL-5 and IL-13 to recruit a different . . . [Full Text of this Article]



   A novel CD4+ T-effector-cell subset distinct from Th1 and Th2
 


   Differentiation and molecular regulation of Th17 cells
 


   Role of Th17 cells in autoimmunity
 


   Current concepts on the role of Th17 cells in immunity
 


   Concluding remarks
 

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