Nephrol Dial Transplant (2003) 18: 788-796
© 2003 European Renal Association-European Dialysis and Transplant Association
Personal dialysis capacity (PDCTM) test: a multicentre clinical study
Background. The assessment of the peritoneal membrane capacity and physiology of the individual patient is becoming increasingly important. It allows the prescription of an individualized peritoneal dialysis (PD)-regimen, and the monitoring of peritoneal membrane function over time. The PDCTM program offers the possibility to evaluate the peritoneal membrane characteristics and to predict solute and water removal by simulation of different treatment regimens.
Methods. This study evaluates the relevance of the PDCTM program when routinely used. The PDCTM data of 336 patients from nine different centres in Europe were evaluated.
Results. The area parameter was 20 985±7578 cm/1.73 m2 (mean±SD). The reabsorption of fluid after dissipation of glucose, JvAR, was 1.97±1.00 ml/min/1.73 m2. The large pore fluid flux, JvL, was 0.11±0.07 ml/min/1.73 m2. A multivariate model for prediction of serum albumin included dialysate protein loss, JvL, JvAR, nPCR, A0/
X, BMI and gender (R2=0.81, P<0.001). Total clearance fell with increasing PD duration (P<0.001). A negative relation between A0/X and ultrafiltration (rho=-0.26, P<0.05), a positive relation between A0/X and peritoneal creatinine clearance (rho=0.52, P<0.05) and urea clearance (rho=0.36, P<0.05), and a positive relation between measured peritoneal creatinine and urea clearance (rho=0.64, P<0.01) was observed.
Conclusions. In summary, the present study shows that the PDCTM program is a robust, accurate method to describe the peritoneal membrane transport characteristics. Analysis of PDCTM data of large groups of patients, especially if followed up over time, can give interesting information on the physiology of the peritoneal membrane and the impact of different parameters on it.
Keywords: PDCTM; peritoneal dialysis; PET test; renal replacement therapy
Correspondence and offprint requests to: W. Van Biesen, Department of Internal Medicine, Renal Division, University Hospital Gent 0K12IA, De Pintelaan 185, B-9000 Gent, Belgium. Email: wim.vanbiesen{at}rug.ac.be
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