NDT Advance Access published online on December 23, 2004
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfh620
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1 Department of Nephrology and Dialysis, ‘Casa Sollievo della Sofferenza’ Hospital, IRCCS, San Giovanni Rotondo, Italy
* To whom correspondence should be addressed. Background. Although the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism has been identified as an independent cardiovascular risk factor (CRF) in the general population and among uraemic subjects, the validity of this association remains controversial. Methods. To verify this hypothesis, we enrolled all subjects on maintenance dialysis treatment from a specific Italian district. We also enrolled, from the same area, 1307 subject to serve as controls. Genomic DNA was obtained and MTHFR C677T gene polymorphisms were determined. After a baseline evaluation, patients were followed-up for 37±13 months, and all cardiovascular events and causes of mortality were recorded. Results. A total of 461 patients (417 on haemodialysis and 44 on peritoneal dialysis) were investigated, and these included patients with and without cardiovascular diseases at baseline. At enrolment, mean age was 58.8±15.6 years and dialytic age was 82±69 months. Genotype frequencies were not different between controls and uraemics. During the follow-up, the mean mortality rate was 8.81%/year, with cardiovascular events as the most frequent cause of death (n = 68, 56.6%). There was no relationship between the MTHFR genotype and cardiovascular morbidity, overall mortality or cardiovascular mortality. Conclusions. In end-stage renal disease, MTHFR C677T polymorphisms were not associated with cardiovascular disease or mortality.
Received June 8, 2004
Accepted September 7, 2004
Original Articles
The C677T methylenetetrahydrofolate reductase gene mutation does not influence cardiovascular risk in the dialysis population: results of a multicentre prospective study
2 Atherosclerosis and Thrombosis Unit, ‘Casa Sollievo della Sofferenza’ Hospital, IRCCS, San Giovanni Rotondo, Italy; Chair of Medical Genetics, University of Foggia, Foggia, Italy
3 Chair of Medical Genetics, University of Foggia, Foggia, Italy
4 Departments of Nephrology and Dialysis, San Severo, Italy
5 Departments of Nephrology and Dialysis, Cerignola, Italy
6 Departments of Nephrology and Dialysis, Foggia, Italy
7 Chair of Nephrology, University of Foggia, Foggia, Italy
Filippo Aucella, E-mail: faucel{at}tin.it
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